Biochemical regulation of Bradyrhizobium japonicum during symbiotic development. Current projects Biochemical and genetic regulation of the metabolic processes that are required for symbiotic nitrogen fixation is the focus of this research program. Rhizobium-leguminous plant symbioses are unique associations in which both the bacteria and the plant undergo complex metabolic and morphological changes. My laboratory is attempting to identify these processes and to elucidate the mechanisms by which these changes are controlled. The primary goal is to determine which factors, genetic and/or biochemical, limit nitrogen fixation and thus plant growth and development. After these limitations are defined, the appropriate generic alterations will then be attempted to enhance plant productivity.