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职称:Professor
所属学校:University of Iowa
所属院系:Medicinal and Natural Products Chemistry
所属专业:Medicine
联系方式:319-335-9903
My laboratory is focused on the development and testing of non-viral gene delivery systems. This typically involves the development of peptides that either bind ionically or covalently to plasmid DNA to direct its targeting across the cell membrane and to the nucleus. We also develop glycopeptides for gene delivery, where the N-glycan mediates cell-specific targeting of DNA and receptor mediated endocytosis. The lab expertise includes solid-phase peptide synthesis, HPLC and MS, plasmid DNA and siRNA formulation, in vitro and in vivo testing of gene delivery systems and bioconjugate chemistry including N-glycan purification and PEGylation of peptides.
1987-91, Postdoctoral Fellow, Department of Biology, The Johns Hopkins University, Baltimore, Maryland 1991-94,Assistant Professor of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio 1995-97, Assistant Professor of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, The University of Michigan, Ann Arbor, Michigan 1997-2001, Associate Professor of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, The University of Michigan, Ann Arbor, Michigan 2001-2010, Professor and Division Head, Medicinal & Natural Products Chemistry, Professor of Pharmaceutics, College of Pharmacy, The University of Iowa, Iowa City, Iowa 2010-present, Professor, Medicinal & Natural Products Chemistry, Professor of Pharmaceutics, College of Pharmacy, The University of Iowa, Iowa City, Iowa
