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职称:Associate Professor
所属学校:Duquesne University
所属院系:Biological Sciences
所属专业:Biology/Biological Sciences, General
联系方式:412.396.4775
My laboratory is interested in understanding the problem of how cells divide and how they faithfully segregate copies of their genomes. Our approach to this problem is to study cell division and chromsome segregation genes in a simple organism accessible to genetic manipulation. The organism I study is the filamentous soil bacterium Streptomyces coelicolor. This mycelial bacterium undergoes an elaborate cycle of cellular differentiation similar to that of certain filamentous fungi. During differentiation, aerial hyphal filaments are partitioned by extensive septation to form uninucleoid cells that further metamorphose into chains of spores.
In unicellular bacteria, cell division is required for growth and therefore is essential. However, my previous results demonstrate that septation is dispensable for vegetative growth of S. coelicolor, but still required for subdivision of aerial filaments during spore formation. Therefore, the advantage of using this system is that it is possible to isolate or construct mutants to analyze bacterial cytokinesis as a nonessential process using this filamentous bacterium while similar mutants would be lethal in unicellular organisms. I hope this approach will identify new genes involved in cell division, particularly those whose products are involved in imparting the positional information as to where the future sites of cell division will be.
