A 3D Vascular Tissue Model for Studying the Link Between Diabetes and Atherosclerosis We are using a 3D human in vitro tissue model that recapitulates the interface between a blood vessel and the surrounding tissue to mimic an allergic inflammatory response. As an allergy sensor, the tissue model can be comprised of patient-specific cells and be used to predict a patient’s response to allergies, possibly better than existing clinical tests, such as the allergy skin test. An Advanced Tissue-Equivalent Respiratory Model to Study Airway Reactivity to Infectious Agents We are using a tissue-equivalent respiratory model that exhibits a normal immunological response against infectious agents, such as the influenza virus, to determine the mechanisms that lead to an excessive inflammatory response and ensuing complications.