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职称:ASSOCIATE PROFESSOR AND DIRECTOR OF GRADUATE STUDIES
所属学校:Georgetown University
所属院系:Department of Biology
所属专业:Molecular Biochemistry
联系方式:+1 202-687-5881
My research group and I are interested in how microbial cells sense environmental conditions and how they use that information to change gene expression to affect cell morphology and physiology. My group has been focused on nutrient sensing in the model organism Saccharomyces cerevisiae and on the morphological changes in the human pathogenic fungus Candida albicans. Visit the Research section for more information on our projects. My group consists of graduate and undergraduate students who work together on projects employing genetic, biochemical and cell biological approaches to answering research questions.
One project investigates how the yeast Saccharomyces senses the abundance of nucleotides as well as other nutrients as they make decisions to continue dividing or to enter stationary phase. Much of the lab's work in the past has been to investigating how transcription of the genes for nucleotide synthesis is regulated. We studied the transcription factors Bas1 and Pho2, and the intracellular signal. Saccharomyces is a model organism that is exceptionally well-suited for molecular, genetic and biochemical approaches. We extended our studies to investigate the roles for the genes encoding transcription factors in the human commensal Candida albicans. We found that strains carrying these mutations are defective in forming hyphal filaments in response to external cues.