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职称:Professor
所属学校:Carnegie Mellon University
所属院系:chemistry
所属专业:Chemistry, General
联系方式:(412) 268-9588
Research Areas Supramolecular chemistry, Metal-containing peptide nucleic acids, Electron transfer, Molecular electronics, Coordination complexes with spin transitions, Mossbauer spectroscopy, Molecular magnetism, Molecule-based materials Hybrid inorganic-nucleic acid structures for nanotechonogy and biological applications Our research is aimed at the use of molecular recognition properties of nucleic acids and transition metal ions to create nanostructures. We have shown that peptide nucleic acids can be used as scaffold for the rational organization of metal ions. Substitution of nucleobases with ligands affords PNA duplexes with affinity for metal ions at predefined positions. The properties of metal-containing duplexes depend on the interplay between interactions specific to the nucleic acid and to the metal ions, e.g. hydrogen bonding and metal coordination. Our results open opportunities for using metal-containing duplexes in biological and nanotechnological applications. Polynuclear complexes with spin transitions for information storage applications Materials that are bistable, i.e. which can exist in two different states under similar conditions, can be used in the construction of information storage devices. Molecules that have a demonstrated ability to exist in two different states, namely states with a different spin are Fe(II) coordination complexes. Depending on the strength of the ligand field of the Fe(II) ions in specific coordination complexes, it is possible that the Fe(II) sites undergo a spin transition between low spin (S = 0) and high spin (S = 2) states. In solid state, intermolecular interactions between the complexes influence the abruptness of the spin transition and can lead to hysteresis, an essential condition for bistability. We study Fe-containing polynuclear complexes that undergo spin transitions because the mechanical and/or exchange interactions between the metal ions in these complexes are easier to characterize than intermolecular interactions and can provide insight in how to rationally design molecule-based, bistable materials.
Research Areas Supramolecular chemistry, Metal-containing peptide nucleic acids, Electron transfer, Molecular electronics, Coordination complexes with spin transitions, Mossbauer spectroscopy, Molecular magnetism, Molecule-based materials Hybrid inorganic-nucleic acid structures for nanotechonogy and biological applications Our research is aimed at the use of molecular recognition properties of nucleic acids and transition metal ions to create nanostructures. We have shown that peptide nucleic acids can be used as scaffold for the rational organization of metal ions. Substitution of nucleobases with ligands affords PNA duplexes with affinity for metal ions at predefined positions. The properties of metal-containing duplexes depend on the interplay between interactions specific to the nucleic acid and to the metal ions, e.g. hydrogen bonding and metal coordination. Our results open opportunities for using metal-containing duplexes in biological and nanotechnological applications. Polynuclear complexes with spin transitions for information storage applications Materials that are bistable, i.e. which can exist in two different states under similar conditions, can be used in the construction of information storage devices. Molecules that have a demonstrated ability to exist in two different states, namely states with a different spin are Fe(II) coordination complexes. Depending on the strength of the ligand field of the Fe(II) ions in specific coordination complexes, it is possible that the Fe(II) sites undergo a spin transition between low spin (S = 0) and high spin (S = 2) states. In solid state, intermolecular interactions between the complexes influence the abruptness of the spin transition and can lead to hysteresis, an essential condition for bistability. We study Fe-containing polynuclear complexes that undergo spin transitions because the mechanical and/or exchange interactions between the metal ions in these complexes are easier to characterize than intermolecular interactions and can provide insight in how to rationally design molecule-based, bistable materials.
