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职称:Professor
所属学校:Wake Forest University
所属院系:Chemistry Department,
所属专业:Chemistry, General
联系方式:(336) 758-3507
Diploma (Chemistry), 1989, University of Oldenburg, Germany Ph.D., 1992, University of Oldenburg, Germany (S. Pohl) Postdoctoral Fellow (German Research Council, DFG), 1992–1993, Leiden University, The Netherlands (J. Reedijk) DFG Research Fellow, 1994–1996, Virginia Commonwealth University (N. Farrell) Research Associate, 1996–1998, Virginia Commonwealth University (N. Farrell) Postdoctoral Research Associate, 1998–1999, University of Minnesota (L. Que, Jr.)
Research in our laboratory is concerned with the design of small-molecule agents for the cure and management of life-threatening diseases and for probing and modulating gene regulation. Structurally novel drugs and drug conjugates are prepared using organic and inorganic synthetic methodologies. The interactions of these agents with potential biomolecular targets (DNA, DNA-processing enzymes, metalloenzymes) are studied using bioanalytical (LC-MS) and high-resolution structural (NMR, X-ray) methods, as well as biophysical and molecular biology techniques. Biological activity studies are carried out in vitro and in vivo by collaborators at WFU School of Medicine. Our research is funded through the National Institutes of Health.
