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职称:Professor Department
所属学校:University of Connecticut
所属院系:School of Medicine
所属专业:Cell/Cellular and Molecular Biology
联系方式: 860-679-2811
Networks involving estrogen receptor-alpha (ERa) signaling, growth factor & cytokine signaling & microRNA expression and function in breast cancer and endometrial cancer. We are currently studying the events involved in epithelial-to-mesenchymal transition (EMT) that induces a switch of ERa-positive Luminal breast cancer to mesenchymal ERa-negative Basal-like, Claudin-Low or Metaplastic forms. This work involves study of microRNAs that specifically target ERa, and their potential regulation by EMT-related growth factors and EMT-effector transcriptional regulators. We are also studying the regulation of expression of metabolic enzymes and metabolic reprogramming in epithelial vs. mesenchymal cancer cells
Kondaveeti, Y., Guttilla Reed, I.K., and White, B.A. (2015). Epithelial–mesenchymal transition induces similar metabolic alterations in two independent breast cancer cell lines. Cancer Letters 364 (2015) 44–58. pdf Guttilla, IK, Phoenix, KN, Hong, X, Tirnauer, JS, Claffey, KP, and White, BA (2012) Breast Cancer Res Treatment,132: 75-85. Prolonged mammosphere culture of MCF-7 cells induces an EMT and repression of the estrogen receptor by microRNAs. pdf Gutilla I.K., Adams, B.D., White, B.A. (2012). ERα, microRNAs, and the epithelial-mesenchymal transition in breast cancer. Trends Endocrinol Metab. 23(2):73-82. pdf Guttilla, IK and White, BA (2009) J Biol Chem 284: 23204–23216 Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. PMID: 19574223. pdf Adams BD, Cowee DM, White BA (2009) Mol Endocrinol 23: 1215-1230.The role of miR-206 in the epidermal growth factor (EGF) induced repression of estrogen receptor-a (ERa) signaling and a luminal phenotype in MCF-7 breast cancer cells. PMCID2718747. pdf Adams, B, Claffey, KP, White, BA (2009) Argonaute-2 Expression is Regulated By Epidermal Growth Factor Receptorand Mitogen-activated Protein Kinase Signaling and Correlates with a Transformed Phenotype in Breast
