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验证码:

Tarek A. Abbas

职称:professor

所属学校:University of Virginia-Main Campus

所属院系:Biomedical Sciences Graduate Program

所属专业:Biochemistry

联系方式:434-243-9222

简介

BA, Hunter College, City University of New York, NY MA, Hunter College, City University of New York, NY MPH, The Graduate Center, (CUNY), NY PhD, City University of New York, Hunter College

职业经历

Abbas T, Keaton M, Dutta A. Genomic instability in cancer. Cold Spring Harbor perspectives in biology. 2013;5(3): a012914. PMID: 23335075 | PMCID: PMC3578360 Abbas T, Keaton M, Dutta A. Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2. Cell cycle (Georgetown, Tex.). 2013;12(14): 2175-82. PMID: 23892434 | PMCID: PMC3755067 Abbas T, Mueller A, Shibata E, Keaton M, Rossi M, Dutta A. CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration. Molecular cell. 2013;49(6): 1147-58. PMID: 23478445 | PMCID: PMC3615078 Park J, Long D, Lee K, Abbas T, Shibata E, Negishi M, Luo Y, Schimenti J, Gambus A, Walter J, Dutta A. The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Molecular and cellular biology. 2013;33(8): 1632-44. PMID: 23401855 | PMCID: PMC3624244 Terai K, Shibata E, Abbas T, Dutta A. Degradation of p12 Subunit by CRL4Cdt2 E3 Ligase Inhibits Fork Progression after DNA Damage. The Journal of biological chemistry. 2013;288(42): 30509-14. PMID: 24022480 | PMCID: PMC3798521 Abbas T, Dutta A. CRL4Cdt2: master coordinator of cell cycle progression and genome stability. Cell cycle (Georgetown, Tex.). 2011;10(2): 241-9. PMID: 21212733 | PMCID: PMC3025761 Shibata E, Abbas T, Huang X, Wohlschlegel J, Dutta A. Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex. Molecular and cellular biology. 2011;31(15): 3136-45. PMID: 21628527 | PMCID: PMC3147600 Van Rechem C, Black J, Abbas T, Allen A, Rinehart C, Yuan G, Dutta A, Whetstine J. The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. The Journal of biological chemistry. 2011;286(35): 30462-70. PMID: 21757720 | PMCID: PMC3162406 Abbas T, Shibata E, Park J, Jha S, Karnani N, Dutta A. CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. Molecular cell. 2010;40(1): 9-21. PMID: 20932471 | PMCID: PMC2966975 Terai K, Abbas T, Jazaeri A, Dutta A. CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis. Molecular cell. 2010;37(1): 143-9. PMID: 20129063 | PMCID: PMC2818832 Abbas T, Dutta A. p21 in cancer: intricate networks and multiple activities. Nature reviews. Cancer. 2009;9(6): 400-14. PMID: 19440234 | PMCID: PMC2722839 Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes & development. 2008;22(18): 2496-506. PMID: 18794347 | PMCID: PMC2546691 Abbas T, Jha S, Sherman N, Dutta A. Autocatalytic phosphorylation of CDK2 at the activating Thr160. Cell cycle (Georgetown, Tex.). 2007;6(7): 843-52. PMID: 17361108 Abbas T, Dutta A. CDK2-activating kinase (CAK): more questions than answers. Cell cycle (Georgetown, Tex.). 2006;5(10): 1123-4. PMID: 16687928 Sivaprasad U, Abbas T, Dutta A. Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells. Molecular cancer therapeutics. 2006;5(9): 2310-6. PMID: 16985065 Hui L, Abbas T, Pielak R, Joseph T, Bargonetti J, Foster D. Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53. Molecular and cellular biology. 2004;24(13): 5677-86. PMID: 15199126 | PMCID: PMC480910 Abbas T, White D, Hui L, Yoshida K, Foster D, Bargonetti J. Inhibition of human p53 basal transcription by down-regulation of protein kinase Cdelta. The Journal of biological chemistry. 2003;279(11): 9970-7. PMID: 14699137 Abbas T, Olivier M, Lopez J, Houser S, Xiao G, Kumar G, Tomasz M, Bargonetti J. Differential activation of p53 by the various adducts of mitomycin C. The Journal of biological chemistry. 2002;277(43): 40513-9. PMID: 12183457

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