Our research focuses on the regulation of myogenic stem cell function in adult life. Our long-term goal is to identify means to ameliorate age-related muscle deterioration (sarcopenia) and combat muscle wasting in muscular dystrophy. We investigate satellite cells, classically defined tissue specific myogenic stem cells that reside beneath the myofiber basal lamina, as well as non-myogenic progenitors associated with the microvasculature that may contribute to myogenesis by myogenic reprogramming.