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职称:Professor
所属学校:University of Connecticut
所属院系:School of Medicine
所属专业:Nutrition Sciences
联系方式: 860-679-3495
The role of mRNA trafficking in myelin and synapse formation.Our laboratory studies the mechanism and regulation of mRNA transport, localization, and translation in oligodendrocytes and neurons. An 11-nucleotide sequence first identified in the 3’UTR of myelin basic protein, a major and essential component of myelin, is also present in several neuronal mRNAs implicated in synaptic plasticity. This sequence is recognized by the protein hnRNP A2 which in turn binds to TOG (tumor overexpressed gene) protein. The function of TOG may be to assemble mRNAs whose proteins function in an interdependent manner, in the same complex or RNA granule so that their translation can be regulated coordinately.
Degree Institution Major Ph.D. McGill University Biochemistry M.S. University of Montreal Biochemistry B.S. University of Montreal Biochemistry B.A. College Jesus-Marie Chemistry Post-Graduate Training Training Institution Specialty Postdoctoral University of Connecticut Cell & Mol. Biology Fellowship Cancer Research Society Graduate Student Fellowship Fellowship EMBO Fellowship Summer Course in Virology Fellowship Conseil de la Recherche en Sante du Quebec Post-doctoral Fellowship Fellowship NATO Fellowship Summer Course in Mammalian Genetics Fellowship Canadian Federation of University Women Margaret McWilliams Traveling Fellowship