After appointments at the North Carolina State University, University of Colorado-Pueblo and the Stevens Institute of Technology, she joined the Department of Mathematics at Case Western Reserve University in 1997, where she is now the James Wood Williamson professor of mathematics. From 2008 to 2014 she was department chair. She is associated with the professional journals Mathematics of Computations, Inverse Problems and Frontiers in Neuroenergetics. Her first research activity was in the area of numerical linear algebra and orthogonal polynomials, with special attention to structured matrices and iterative methods for large-scale linear systems. As she started working on the numerical solution of discrete inverse problem, her research began including elements of Bayesian inference to account for information of qualitative type into the solution