The long-term research goals of my laboratory are to understand patterns of genetic variation within and between populations and to use this information to address fundamental problems in Biology and Evolution. To this end, we are pursuing research projects in two broad and interrelated areas: 1) human population and evolutionary genomics and 2) delineating the genetic architecture of quantitative traits and complex diseases. The goals of these studies are to understand the genetic structure of human populations, infer important demographic events in human history, identify regions of the genome that have been affected by natural selection, and map genes that contribute to susceptibility of complex diseases and mediate inter-individual variation in quantitative traits. The raw data that we use to answer the questions described above include whole genome DNA sequence information and massively parallel measures of gene expression, protein, and metabolite levels. These data sets are inherently complex and quantitative, and we develop theoretical, statistical, and computational tools to extrapolate meaningful information from them.