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职称:PROFESSOR
所属学校:University of Washington-Seattle Campus
所属院系:Immunology
所属专业:Immunology
联系方式:206-685-7120
Dr. Bevan received his Ph.D. in Immunology at The National Institute for Medical Research int Mill Hill, London, in 1972. Prior to joining the University of Washington in 1990, he held positions at Scripps Research Institute in La Jolla, California, the Massachusetts Institute of Technology,and The Salk Institute. He retired Sept. 1, 2015, from his position as a Howard Hughes Medical Institute Investigator. He is a Fellow of the Royal Society of London, and a member of the U.S. National Academy of Sciences.
T lymphocytes mature in the thymus and recognize "processed" forms of antigens presented by major histocompatibility complex-encoded molecules. Dr. Bevan's laboratory studies CD8+ cytotoxic T lymphocytes (CTL) which recognize peptide fragments of proteins of viral or bacterial origin bound by class I MHC molecules. The goal of experiments in the Bevan laboratory is a detailed description of how cytotoxic T cells mature, how the responses to foreign antigen is regulated, the processes whereby these antigens are presented in vivo, and how long-lived protective memory to pathogens is achieved. In response to pathogen infection, CD8+ cells can go through 15 or more cell divisions within 6 days to generate millions of cytotoxic effectors.
