My lab has two projects, both employing C. elegans as a model system, and using genetics, biochemistry and imaging techniques. In one project, we study the function of neuromodulators, molecules that regulate neuronal properties to control our moods, emotions and appetites. We study how neuromodulators are packaged into dense-core vesicles, how these vesicles are trafficked and released, and how cells respond to neuromodulatory signals. We have identified a novel Rab pathway that regulates dense-core vesicle maturation, as well as a novel G protein signal transduction pathway that controls the response to neuromodulatory signals. These studies will provide new insights into the molecular mechanisms of neuromodulation and may be relevant to disorders of the nervous system such as autism, schizophrenia, and eating disorders.