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职称:Professor
所属学校:University of Georgia
所属院系:Arts and Sciences
所属专业:Cell/Cellular Biology and Histology
联系方式: (706) 542-3409
The ability of eukaryotic cells to adopt variable shapes, to move in different directions, or to distribute cellular components within the cytoplasm is controlled by a network of filaments: the cytoskeleton. Microtubules provide intracellular tracks for organellar transport performed by motor proteins (kinesins and dyneins). One unaswered question is how motor proteins and other microtubule-binding proteins recognize specific microtubules. We explore a model that distinct types of microtubules are adapted for specific functions by localized post-translational modifications of the building blocks of microtubules, tubulin subunits. Currently, we study the function of tubulin modifications in the assembly and function of cilia, conserved organelles that play key roles in cell motility and signal transduction. Recently, we have also initiated projects aimed at understanding how tubulin modifications contribute to assembly and function of microtubules in nerve cells.
We have shown that amino acids used by polymodifications (glutamylation and glycylation) on tubulin are essential for assembly of cilia. We have contributed to the discovery of enzymes that generate polymodifications: tubulin E-ligases and G-ligases. We use the microtubule-rich protist Tetrahymena thermophila, and zebrafish as models. Current research projects include studies on: 1) tubulin modifying enzymes that generate polymodifications (E-ligases and G-ligases) and their function in ciliary motility and assembly; 2) role of tubulin acetylation in neuronal development; 3) identification of novel enzymes that generate tubulin modifications; 4) identification of novel conserved types of tubulin post-translational
