简介

Our laboratory is interested in understanding the mechanisms controlling mammalian development and cell differentiation. We study the epigenetic functions of chromatin proteins and transcription factors in control of gene expression in embryonic stem cells, in red blood cells, and in Drosophila. Our approaches involve directed gene inactivation and transgenesis in mice and Drosophila. We also study control of proliferation and differentiation in red blood cell progenitors and in leukemia cells in which normal development is disrupted. Currently there are two major projects underway in the lab.