Prof. Omenetto's research is heavily focused on interdisciplinary themes that span nonlinear optics, nanostructured materials (such as photonic crystals and photonic crystal fibers), optofluidics and biopolymer based photonics. The laboratory has pioneered the use of silk as a material platform for photonics, optoelectronics and high-technology applications and is actively investigating novel applications that rely on this new technology base. The laboratory leverages tools and methods based on tunable femtosecond optical pulses (such as 2D and 3D micromachining of organic and inorganic materials) , and carries out research on new fiber-based and nanostructured based devices (such as photonic-crystals, nanoplasmonics, and photonic crystal fibers) for the development of new approaches for biological sensing and imaging.