专业描述

Tumor promoter-induced signal transduction pathwaysCarcinogenesisCancer prevention The major focus in the Cellular and Molecular Biology section is the molecular mechanisms of cancer development and the actions of chemopreventive agents in cancer prevention. The tumor promotion stage is a rate-limiting step in cancer development (carcinogenesis) and therefore understanding the molecular mechanisms in this step is important for progress toward cancer prevention. We address response of mammalian cells to tumor promoters at the level of transcription factors and protein kinases. Our research examines the tumor promoter-induced signal transduction pathways and their role in the process of neoplastic cell transformation, carcinogenesis, and cancer prevention with the following: molecular and cell biological techniques transgenic mice mouse gene-knockout models Another main emphasis of our lab is the elucidation of mechanism(s) of the anticancer actions attributed to several chemopreventive compounds. These are compounds considered to have little or no toxicity and are present in commonly consumed foods and beverages.